Phosphatidyserine (PS) has been clinically shown to balance cortisol levels which are at the root of chronic stress's effects on the brain. This cream is the most economical and efficient manner to receive sufficient levels of PS to lower cortisol.
Vitamins and minerals make changes at a cell level, to break this mold we need to change the body at a central level - the BRAIN. It is this lack of understanding of how deeply Adrenal Stress Syndrome impacts human physiology that makes resolution of this abnormal functional pattern difficult for the clinician and you.
The hippocampus is a ridge in the floor of each lateral ventricle of the brain that consists mainly of gray matter and has a central role in memory processes. Elevated cortisol has also shown to cause hippocampal cell destruction due to excitotoxicity of cortisol sensitive hippocamapal cells. Phosphatidyserine has been shown to have some ability to reverse hippocampal cell destruction responsible for poor memory.
Simply stated, enough stress kills you after a while. Why not slow it down?
A vicious cycle exists between the hippocampus and the HPA axis because the hippocampal neurons are rich in glucocorticoid receptors and very sensitive to cortisol. Therefore, when the body is placed in a chronic stress response, the hippocampus has prolonged exposure to cortisol. Since its cells are sensitive to cortisol, prolonged exposure initiates neuronal cell death by excitoctoxicity and ultimately leads to hippocampal glucocortioid receptor down regulation, neuronal death, and HPA negative feedback insensitivity.
The excitotoxic hypothesis from cortisol in the hippocampus is based on the influence of cortisol on glucocorticoid receptors which have an impact on the neuronal transmembrane gradient rendering the NMDA receptor more receptive to glutamate. The resulting influx of calcium enhances reactive oxygen species generation, which further damages mitochondrial activity in a self-propagating feed forward cycle leading to cell death.
The vicious cycle that develops in adrenal stress syndrome may explain why some people do not respond as effectively to adrenal support as others. If the person has been in a chronic stress pattern, they may not poses the ability to regulate function. The classical pattern, with a loss of HPA axis, is the patient that has developed an inability to deal with stress over a period of time. These people will also be those that never seem to stabilize when the adrenals are supported, but always show a need for some type of adrenal support.
The chief complaint with patients that have some hippocampal loss of function, is loss of short term memory, in addition to unstable and unpredictable adrenal stress syndrome's symptoms. To reset this pattern use K-2 Adaptocrine, K-16 Adrenal Calm, as well as the others metioned on this page.
These patients may present to the clinician as a difficult case because the clinician is ignoring the importance of re-establishing proper HPA axis and therefore can never unlock the metabolic pattern associated with adrenal stress syndrome. Objectively, these patterns can be observed from an adrenal salivary index that presents with adrenal hyperfunction, or a pattern that reflects an elevated level of cortisol at midnight. In other words - tired in the morning and wired at night. To reset this pattern use K-2 Adaptocrine, K-16 Adrenal Calm, and Sublingual Vitamin B12 Liquid all from Apex.
Simply stated, if you have high levels of adrenal hormones when tested with saliva (which is the cheapest and easiest way to measure the Adrenal Glands) you need to reset the high out put before they are burnt out.
Elevations of midnight cortisol suggest lack of sensitivity to suppression of the HPA axis. However, it should be noted that any abnormal adrenal profile can indicate loss of HPA axis. Treatments with agents such as phosphorylated serine in K-16 Adrenal Calm and other compounds that have shown to suppress this vicious cycle should be considered. (Apex Adaptocrine and Sublingual Vitamin B12 Liquid).
It should also be made clear that once cortisol levels are lowered, changes in the hippocampus are reversible and the potential to optimize the hippocampus-HPA axis can be restored, but this process is not immediate. Be patient. It took years and years of stress that burn out your brain, it will take so time and persistance to correct. In addition, once one understands the impact of cortisol on the hippocampus, excitotoxicity, glucocorticoid receptor down-regulation, neuronal death, and insensitivity of the HPA axis negative feed back loop, the use of exogenous cortisol to treat adrenal stress syndromes seems illogical.
Many Medical doctors will attempt to use some form of steroids like prednisone to temporarily give relief but this bypasses the body's own attempts to make its own anti-inflammatory hormones. It may work once in a while, but after that it fails and the side effects and loss of feedback as well as damage may become irreparable.
Exogenous cortisol therapy may cause the patient to feel better immediately, but it feeds the vicious cycles that will make the appropriate physiological changes that need to be corrected for adrenal stress syndrome extremely difficult down the road.
In my personal experience, it is extremely difficult to re-establish proper feedback control with patients that have been on cortisol therapy for adrenal stress syndrome or any other disorders. That means we try and often fail when we are years too late.
Provides support for memory, cognition, and the management of anxiety.
PHOSPHATIDYLSERINE (PS) is an endogenously produced phospholipid that is embedded in cell membranes and is the major phospholipid in the brain. Its general functions include supporting cellular chemical signal transmissions, activating cell surface receptors, and cellular exchange of nutrients and waste products.