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There is a lot of exciting news about RESVERASIRT

The key is having a 99.9% or higher form of Trans RESVERASIRT, the other forms and less pure forms are not active in changing the life extension gene, Sirtuins.

Resveratrol (Trans not Cis form) is known to stimulate production of a class of enzymes called Sirtuins, labeled in mammals as SIRT-1 through SIRT-7. Sirtuins are known to affect cellular metabolism via selective gene expression, including cell survival, fat metabolism, insulin resistance and generalized cell repair (anti-aging).

A number of beneficial health effects, such as anti-cancer, antiviral, neuroprotective, anti-aging, and anti-inflammatory effects, have been reported in lab tests using the compound Pure Trans RESVERATROL.

Biotics Research Corp has developed another Resveratrol-containing product called ResveraSIRT-HP. This was accomplished in conjunction with Mark Houston, M.D. after 3 years of research. Dr Houston is Associate Clinical professor of Medicine at Vanderbilt School of Medicine. He has written a book called, "What Your Doctor May Not Tell You About HypertensionTM: The Revolutionary Nutrition and Lifestyle Program to Help Fight High Blood Pressure.

This new product is a very high potency resveratrol product. Specifically, this products is used to support a healthy vascular system and to promote healthy aging. Most people in this country will suffer from diseases that may greatly benefit from these high quality and researched products in ResveraSIRT-HP.

In lab testing with various animals (most scientists feel these studies can be applied to humans as the gentics codes are almost identical) Sirtuins play key roles in:

* Gene silencing -inhibiting the expression of different genes

* DNA repair - allowing proper coding to be expressed.

* DNA recombination- the process that a DNA segment moves from one DNA molecule to another DNA molecule

* Aging - associated with increased rates of stress-induced cell death.

* Cell survival

* Energy metabolism

* Response to stressors

Research on resveratrol has documented improved health and survival of animals on high calorie diets. Caloric restriction in lab animals results in a 50% increase in lifespans. Resveratrol, by stimulating the anti-aging enzymes SIRT-1 through SIRT-3 acts similarly to caloric restriction. Caloric restriction increases mitochondrial functions in humans and animals thereby resulting in increased energy production in the cell.

This compound provides additional antioxidant activity, and has been shown to be very cardio protective and very vascular protective, to inhibit angiogenesis (atherosclerosis) and to down regulate proinflammatory mediators. Resveratrol helps to improve insulin sensitivity and carbohydrate metabolism.

Each capsule of ResveraSIRT-HP supplies 250mg of pure Trans Resveratrol. Quercetin, a bioflavanoid, is added to help slow the metabolism of Resveratrol, since it is metabolized quickly. Also included is IP6 (Calcium Magnesium Phytate), a 6-phosphate ester of Inositol derived from rice. IP6 is also a supporter of the cardiovascular system and aids in the metabolism of insulin. It is used in this supplement for its metal chelating activity to help stabilize the the formula.

As a result of extensive news coverage, sales of resveratrol supplements greatly increased in 2006. There is also concern in the scientific community that many of the currently-available resveratrol supplements contain little or none of the active ingredient.

Because of Biotics'' reputation in the healthcare and research community physicians and patients can rest-assured that this is the finest most pure supplement of resveratrol on the market. It had better be because the "real stuff" is expensive.

If you look up the cost of resveratrol in a chemical book you can see: Spectrum Chemicals offers pure resveratrol for $35 per 50 mg. That is the pure stuff. Biotics, because they buy resveratrol by the kilogram offers 250mg capsules for a lot less.

Current Research

Resveratrol, Sirtuins and the Extended Lifespan

We would like to discuss some of the some new and exciting research behind the

phytochemical Resveratrol and how it can modulate various aspects of metabolism and the

aging process. First let us review some genetic terms so that we can understand exactly how

Resveratrol modulates genetic expression.

Inside the nucleus of every mammalian cell are two

strands of DNA (1 from mom, 1 from dad), coiled tightly in a double helix. Each DNA strand

has 26 pairs of chromosomes (46 total per cell) that contain many genes, regulatory sequences, and when activated transcribe (synthesize) proteins. These proteins are then modified,packaged, and either utilized by the cell or transported to other cells/tissues. The activation of genes is a highly controlled, tightly regulated system, through the action of cellular messengers that is well beyond the scope covered here.

Histones

Each strand of DNA is roughly 2 meters (6 feet) in length, yet is able to fit inside a cell

smaller than 1 micron because of proteins called histones. These proteins are analogous to a

cellular fishing real, they wind DNA so efficiently and tightly that it is compacted to a fraction

of its size and protected from potential damaging free radicals (reactive oxygen species), UV

radiation, X rays, and many others. Damage to DNA can lead to aberrant protein synthesis and

unregulated cell growth (i.e. cancer) and although cells have endogenous repair mechanisms,

it’s imperative that DNA be compact and protected. Resveratrol has antitumor activity and has

been shown to arrest unregulated cell growth and induce apoptosis (programmed cell death) in aberrant cells (6).

Histone Modification and Protein Synthesis

Gene transcription and subsequent protein synthesis could not occur if Histones were

tightly bound to proteins all the time-the process is modifiable via chemical modification called acetylation or methylation. When a cell needs a certain protein it sends signals to activate genes, which are made accessible because the histones surrounding that region of DNA is acetylated (made more water soluble). The addition of the acetyl groups reduces the affinity for histone- DNA-binding, causing histones “to open up“ around the DNA, thus allowing genes to be accessible for transcription factors and protein synthesis. Hyperacetylated DNA is trasncriptionally active. After the desired proteins are made the acetyl groups are removed by enzymes called histone deactylatses, exposing the amino acid tails of the histones to DNA, making it more compact and protected with the amino acid side chains of histones having an affinity for DNA. Resveratrol is a natural histone deacetylase enzyme.

Quick review: Histones are proteins that compact and protect DNA, when acetylated they open up to allow for protein synthesis, when deacetylated they re-compact around DNA.

Sirtuins: Modulators of Acetylation

A group of genes called silent information regulators, AKA sirtuins, do just that; they

enzymatically “silence the information of DNA” through the removal of acetyl groups from

histones. The most well studied of these protein modifying enzymes is SIRT 1, which has been shown to be up regulated in states of caloric restriction (CR). In the 1930’s researchers found that CR in lab animals extended lifespan but didn’t know the mechanism. It has been elucidated that CR is a mild biological stressor which actives sirtuin genes (2).

Wei-jian wrote an excellent review article about Sirtuins (posted on our website) stating,

“Evidence suggests that activation of SIRT1 leads to multiple metabolic improvements

including enhanced glucose utilization, improved insulin sensitivity and increased exercise

tolerance” (1).

Resveratrol- Sirtuin activator

Harvard researcher David Sinclair put Resveratrol (RSV) on the map after publishing a

paper in Nature, which showed that when RSV was given to rats consuming a high caloric diet

it produced “changes associated with longer lifespan, including increased insulin sensitivity, reduced IGF-1... increased mitochondrial number, and improved motor function” (3).

A study published in Cell by Lagouge et. al found “Treatment of mice with RSV

significantly increased their aerobic capacity....and protected mice against diet-induced obesity and insulin resistance” (4).

An extensive review published by Hall in the journal Science, found that RSV increases

DNA stability, speeds cellular repair, increases total life span, inhibits tumor initiation,

reduces Blood Pressure, lipids, glucose, improves immune function, reduces cancer risk, improves exercise tolerance and weight loss (5).

Conclusions

In last 5 years hundreds of studies have been conducted using the phytonutrient

Resveratrol, showing it to be beneficial in many applications of glucose regulation, vascular and DNA protection, and enhanced longevity. It should be noted that subsequent studies have found that trans-Resveratrol (not cis) is the only bioactive form.

As such Biotics Research has recently developed ResveraSirt-HP: A high potency, 250 mg capsule, containing a 99% standardized extract of trans-resveratrol (the highest potency available) derived from the roots of Polygonum cuspidatum (Japanese knotweed). For more information or questions regarding the product above, contact us at www.myvits.com

References

1) Wei-jian Jiang. Sirtuins: Novel targets for metabolic disease in drug development. Biochemical and Biophysical Research Communications. Volume 373, Issue 3, 29 August 2008, Pages 341-344

2) Small molecules that regulate lifespan: evidence for xenohormesis.Mol Microbiol. 2004 Aug;53(4):1003-

3) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444, 337-342. August 2006.

4) Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1á. Cell.

Volume 127, Issue 6, 15 December 2006, Pages 1109-1122.

5) Hall, S. Longevity research. In vino vitalis? Compounds activate life-extending genes. Science, 2003; 301 (5637)

6) Signorelli. Et. Al Resveratrol as an anticancer nutrient: molecular basis, open questions and promises. The Journal of Nutritional

Biochemistry. Volume 16, Issue 8, August 2005, Pages 449-466

Suggested Use : Recommendation: One (1) capsule one (1) to four (4) times daily as a dietary supplement or as otherwise recommended by your healthcare professional.

Manufactured by : Biotics Reserch ®